Why a high animal protein diet in middle ages may increase risk of death

You may have heard about the benefits of high protein diets:

  • Appetite control
  • Increase muscle mass
  • Bone health
  • Boosts metabolism and Fat burning
  • Lowers blood pressure
  • Maintains weight loss
  • Supports kidney health

However, it is important to point out that these benefits are mainly attributed to plant-based proteins and not so much for animal proteins.  This is because a high animal protein diet, which is often wrongly associated with Atkins diet, increases a growth factor called IGF-1 (insulin like growth factor).  As the name implies , IGF-1 looks like insulin but instead of lowering blood sugar, IGF-1 enhances cellular growth pathways.  IGF-1 has benefits but too much IGF-1 can play a role in cancer development and increasing mortality.  Scientists stumbled across this phenomena when looking at patients in a remote part of southern Ecuador called Quito Ecuador. These patients suffer from Laron syndrome which is a genetic condition that leads to stunted growth. People with Laron syndrome rarely grow beyond 3 1/2 feet tall. The genetic mutation results in the IGF-1 not functioning normally which results in their stunted growth, but amazingly, they never get cancer nor diabetes !

Now, for people who don’t have Laron syndrome, how can they apply this knowledge to improve their health, reduce risk of  cancer and diabetes? They should focus on getting the majority of their protein intake from plant sources. Animal protein is similar to human protein and this explains why animal protein will cause a rapid spike in IGF-1. In contrast, plant-based protein is less similar to animal protein and will increase IGF-1 to a much lesser degree. If you compare this to a volume dial, animal protein is turning the volume to full blast whereas plant-based protein is set to low volume setting.

Do mushrooms have anticancer properties?

The answer to this question is yes.  I am not suggesting that mushrooms can cure cancer but they can have positive impact on helping the immune system fight cancer. How is this possible you ask? Well, to answer that question you need to understand how tumor cells promote tumor development.  Tumor cells release inflammatory cell signaling molecules called cytokines such as transforming growth factor-β (TGF-β) and interleukin-10 (IL-10) which transforms macrophages into a type that promotes cancer.  There are two types of macrophages: M1 and M2. M1 is characterized by resisting the development of tumors and M2 is characterized by the development of tumors. As with tumor cells, M2 macrophages also secrete transforming growth factor-β (TGF-β) and interleukin-10 (IL-10) and this adds fuel to the fire.  This  leads to tumor cells evading detection by the immune system and spreading of tumors (metastases). So, is there a way for the body to  create an anti-tumor environment full of M1 macrophages? The answer is yes and this is where mushrooms can help.  It turns out that mushrooms contain a polysaccharide called beta-glucan which can change the tumor environment by making more M1 macrophages.